Total Bladder Protection

1. Bladder leaks is also known as OAB or an overactive bladder that affects over 50 million Americans. OAB is not a disease yet a complex symptom of a non life-threatening condition. While there is no cure for OAB, there are many treatments available as well as dietary adjustments that can help improve bladder leaks. Prescription medications are available; however, they have many side effects that patients often stop taking the medication within 3 months. Rejoice® has no side effects and is easy to take with once a day dosing. With continued use of Rejoice Plus®, you will see improvement in about 6 weeks. Use Rejoice Plus® in conjunction with Kegel exercises and dietary changes to see maximum benefits.
2. You should always check with your doctor prior to starting any new therapies as many things can lead to changes in bladder control. Constipation, changes in medication, weight gain, menopause, and general aging can be potential reasons for experiencing occasional urinary urgency and changes in daily bathroom routine.

1. Urinary Tract Infections (UTIs) can occur in any part of the urinary tract: kidneys, bladder, or urethra. “UTIs typically occur when bacteria enter the urinary tract through the urethra and begin to multiply in the bladder.” E. coli is the most common bacteria that cause UTIs, which makes up about “85% of UTIs and 90% of cases of acute pyelonephritis.”  According to the National Institutes of Health, “UTIs are the most common outpatient infections in the United States (US). With the exception of a spike in young women aged 14−24 years old, the prevalence of UTIs increases with age.2 The prevalence in women over 65 years of age is approximately 20%, compared with approximately 11% in the overall population. Between 50% and 60% of adult women will have at least one UTI in their life, and close to 10% of postmenopausal women indicate that they had a UTI in the previous year.”
2. Common Symptoms of UTIs include:
   • A strong, persistent urge to urinate
   • A burning sensation when urinating
   • Passing frequent, small amounts of urine
   • Urine that appears cloudy
   • Urine that appears red, bright pink or cola-colored — a sign of blood in the urine
   • Strong-smelling urine
   • Pelvic pain, in women — especially in the center of the pelvis and around the area of the pubic bone
3. Your doctor may prescribe antibiotics for UTIs, taken up to 3x per day for a few days. However, if you experience frequent UTIs, your doctor my have you take a low-dose antibiotic for an initial 6 months or so. For a severe UTI, you may need treatment with intravenous antibiotics in a hospital. Antibiotics do have the risk of side effects, which may lead patients to stop taking them. Cran-B-PAC® does NOT contain bromelin, which is known to cause interactions with patients who are taking antibiotics, anticoagulants, and/or antiplatelet drugs.
4. You should always check with your doctor prior to starting any new therapies as many things can lead to UTIs. Women are more prone to UTIs due to their urethra, which is shorter than a man’s urethra. Risk factors for UTIs may include: sexual activity and having a new sexual partner; women who use diaphragms for birth control may be at higher risk, as well as women who use spermicidal agents; and menopause.

Cran-B-PAC is an over-the-counter liquid supplement for maintaining a Healthy Urinary Tract & Preventing

1. Cranberry Concentrate contains PACø (Proanthocyanidins), which is found naturally in cranberries. PAC exhibits potent bacterial anti-adhesion activity at 36mg PAC.* 1 oz of Cran-B-PAC® = 10 oz of cranberry juice cocktail.

   *Critical Rev Food Sci Nutrition 2002 42 (3 suppl) 273-18
   øWhole fruit cranberry powder standardized to contain 36 mg

   proanthocyanidins (PAC) per BL-DMAC standard method.

2. D-Mannose + Erythritol are natural sugars, which are excreted in the urine, help displace bacteria from attaching to the urinary tract wall & bladder.
3. Vitamin C helps lower the pH of urine, making it more acidic thus creating a less tolerable environment for bacteria to grow.
4. Prebiotic Inulin helps regulate the bowels and decreases constipation, thereby relieving the strain or pushing on the bladder which can increase leakage. If you are constipated, the intestines will have extra pressure on the bladder, resulting in more frequent urination and bladder leaks.

Rejoice Plus® is the first and only over-the-counter liquid supplement for overactive bladder for both men and women. Rejoice Plus® contains 5 all-natural, active ingredients that support the bladder for 24 hours, day and night.

1. Hyperpure Pumpkin Seed Extract relaxes the muscles of the bladder wall and increases the capacity to hold urine. Pumpkin seed extract has an anabolic effect to help strengthen the pelvic floor and sphincter muscles.
2. L-Citrulline & L-Arginine increases nitric oxide which causes muscle relaxation and increases the ability to hold urine. Nitric oxide helps the blood vessels to flow easier. As a result, it causes the muscles to relax and lower blood pressure so your body is not working as hard. These natural ingredients can be found in foods such as watermelon and chicken.
3. Vitamin D3 increases pelvic floor muscle strength and efficiency; in addition to causing muscle relaxation and decreased contractibility. Vitamin D3 also supports healthy bones and muscle strength.
4. Prebiotic Inulin helps regulate the bowels and decreases constipation, thereby relieving the strain or pushing on the bladder which can increase leakage. If you are constipated, the intestines will have extra pressure on the bladder, resulting in more frequent urination and bladder leaks.

Shake well before using.

Cran-B-PAC® Dosing

• Take alone or mix with other beverages
• Used orally or through GT tubes (1oz serving size)
• For daily usage, take 2 tbsp, 1x-2x per day
• With antibiotics, take 2 tbsp, 1x-2x per day
• Catheter users, take 2 tbsp, 2x per day
• 1 oz of Cran-B-PAC® = 10 oz of cranberry juice cocktail

Rejoice Plus® Dosing

• For the first two weeks, take 3 tablespoons, 1 time per day.
• After the initial two weeks, take 2 tablespoons, 1 time per day.
• This recommended dosage is derived from the clinical studies, indicating that a larger serving in the first two weeks helps promote a steady state. Benefits can be maintained from ongoing smaller amounts.
• Please allow 6-8 weeks to realize full benefits.

Please consult your healthcare professional before taking any new supplement or medication. If you are allergic to any ingredient in Cran-B-PAC® or Rejoice Plus® consult with your physician.

1. If you are experiencing any symptoms you haven’t experienced before, please contact your professional healthcare provider. We also encourage you to report any suspected side-effects to us.
2. Cran-B-PAC® & Rejoice Plus® does not contain soy, a well-known allergen, or any known allergen.
3. Cran-B-PAC® & Rejoice Plus® does not contain any known allergens such as gluten, milk, yeast, peanuts, or eggs.
4. Cran-B-PAC® does not contain Bromelain, which causes an interaction with Warfarin & some antibiotics

Consult with your healthcare professional to ensure that the supplements and medications you are taking are not affected by Cran-B-PAC® or Rejoice®. In the clinical studies, Hyperpure pumpkin seed extract did not interfere with other medications.

This product is safe to use every day when used as directed. Do not use if pregnant, nursing, or under the age of 18 years old. Consult with your physician or pharmacist prior to starting any new therapies.

Rejoice Plus® is safe for diabetics and renal patients too! In both formulations, each dose is sugar-free. Zero grams of sugar and 6 grams of carbohydrates.

Cran-B-PAC® does not contain Bromelain, which causes an interaction with Warfarin & some antibiotics

Studies performed show efficacy in as little as two weeks. Your body may respond faster or slower, so a minimum of up to 6-8 weeks is needed to realize full benefits. Continued daily maintenance with Rejoice Plus® is necessary for the effects to continue.

Cran-B-PAC® Clinical Trials

Clinical trials were performed on PAC (proanthocyanidins), which is contained in the Cran-B-PAC® cranberry concentrate ingredient. The standardization to contain 36 mg of proanthocyanidins per BL-DMAC standard method.

Rejoice Plus Clinical Trials

Clinical studies have been performed on the active ingredients found in Rejoice Plus®. Hyperpure Pumpkin Seed Extract is a well-known ingredient that has helped with urinary leakage for over one hundred years. We use a specialized pumpkin seed in our formulations with proven results that show decreases in urinary and stress incontinence as well as an increase in sleep satisfaction and overall quality of life. Feel free to contact us for more information on the clinical studies on the ingredients found in Rejoice Plus®.

1. Results showed using Hyperpure Pumpkin Seed Extract
   1. 79% decrease in urinary incontinence
   2. 68% decrease in stress incontinence

The shelf life of Cran-B-PAC® is 2 years, while the shelf life Rejoice Plus® is 18 months.

Store them at room temperature (68–72 °F). Discard 60 days after opening. Do not use if the seal is broken. Do not drink from the bottle.

Clinicians should provide education to patients regarding normal lower urinary tract function, what is known about OAB, the benefits vs risks/burdens of the available treatment alternatives and the fact that acceptable symptom control may be require trails of multiple therapeutic options before it is achieve. Clinicians should explain what is normal can help the patient understand their condition and give a comparator for establishing mutually-identified and realistic goals for treatment.

Clinicians should also offer behavioral therapies (bladder training, bladder control, pelvic floor muscle training, fluid management) as first-line therapy to all patients. Cran-B-PAC® & Rejoice Plus® should be added to the regiment since it is exceptionally well-tolerated, safe, effective, and non-invasive. Behavioral treatments are a group of risk-free tailorable therapies that improve individual symptoms by changing patient behavior.